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Immune responses are involved in the pathophysiology of Parkinson’s disease. Supporting evidence for these responses and the emerging roles of microglia and astrocytes was presented by experts at MDS Virtual Congress 2020.
Immune responses play a role in the pathophysiology of Parkinson’s disease (PD),1 said Professor David Sulzer, New York, NY. Evidence for this role has been provided by a number of studies:
Microglia are activated by extracellular neuromelanin
α-synuclein-specific T cell responses are highest shortly after a diagnosis of motor PD
Astrocytes contribute to dopaminergic neurodegeneration in PD
Research carried out by Professor Antonella Consiglio, Barcelona, Spain, and her colleagues supports the role of astrocytes in PD pathophysiology.
α-synuclein accumulates in control cells co-cultured with PD astrocytes
She described the studies of iPSC-derived astrocytes and neurons from familial mutant LRRK2 patients with PD and healthy individuals that demonstrated:
Our correspondent’s highlights from the symposium are meant as a fair representation of the scientific content presented. The views and opinions expressed on this page do not necessarily reflect those of Lundbeck.